Intraperitoneal distribution of alginate microcapsules in mice
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چکیده
منابع مشابه
Intraperitoneal distribution of alginate microcapsules in mice
Introduction: Improved drug delivery mechanisms for the treatment of residual peritoneal cancer cells following cytoreduction surgery are needed. Alginate microcapsules are a potentially useful mechanism for delivery of bioengineered cells, but when injected into the peritoneum, their distribution and properties are not well described. Methods: Aliquots of 300, 600 or 1200 microcapsules were in...
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An alternative approach to somatic gene therapy is to deliver the therapeutic protein by implanting genetically modified cells that could overexpress the gene of interest. Microencapsulation devices were designed to protect cells from host rejection and prevent the foreign cells from spreading while allowing protein secretion. Alginate microcapsules form a semi-permeable structure that is suita...
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In order to improve its stability and catalytic rate in flour, the immobilization of glucose oxidase (GOX) was investigated in this work. The enzyme was encapsulated in calcium alginate-chitosan microspheres (CACM) using an emulsification-internal gelation-GOX adsorption-chitosan coating method. The interaction between alginate and chitosan was confirmed by infrared spectroscopy (IR). The resul...
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Objective(s): There is a rising use of gold nanoparticles (AuNPs) in goods and in the medical fields but there is concern about the toxicity of them. So in this study spherical AuNPs with 3 different concentrations were applied for investigating their effects in vivo. Materials and Methods: 40 male albino mice were randomly divided into sham, control, 25 ppm, 50 ppm, 100 ppm groups and were...
متن کاملAlginate Microcapsules as Nutrient Suppliers: An In Vitro Study
OBJECTIVES Alginate, known as a group of anionic polysaccharides extracted from seaweeds, has attracted the attention of researchers because of its biocompatibility and degradability properties. Alginate has shown beneficial effects on wound healing as it has similar function as extracellular matrix. Alginate microcapsules (AM) that are used in tissue engineering as well as Dulbecco's modified E...
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ژورنال
عنوان ژورنال: Modern Chemotherapy
سال: 2014
ISSN: 2169-348X,2169-3498
DOI: 10.4236/mc.2014.31001